The proposed control device (1) for motor unit (2) that can be fixed to a wheelchair (3) comprises: a control lever (11) articulated to the handlebar (6) of the motor unit (2) a support element (12) fixed to the control lever (11) lower (13) and upper (14) end stroke means, connected to the support element (12) and extending parallel to the part (60) of the handlebar (6), which can be held by the user with the wearers wrist that, when holding the graspable part (60) of the handlebar (6), can be positioned interposed between said lower (13) and upper (14) end stroke means (14), so as to allow the user to activate the control lever (11) fixed to the support element (12) by means of the rotation with the rotation of the control lever (11), led by the users wrist, which allows the activation of the control means of the motor unit (2) acting on the electric motor and/or on the braking disk (9) to adjust the speed and/or the braking action.