Michelle Dawn Garrett;Thomas Glanmor Davies;Robert George Boyle;Ian Collins
发明人:
Thomas Glanmor Davies,Robert George Boyle,Ian Collins,Michelle Dawn Garrett
申请号：
US11993831
公开号：
US08343953B2
申请日:
2006.06.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom； and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom α with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom α with respect to the NR2R3 group； E is a monocyclic or bicyclic carbocyclic or heterocyclic group； R1 is an aryl or heteroaryl group； and R2, R3, R4 and R5 are as defined in the claims.
