Embodiments of the invention generally provide pharmaceutical durg compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating antidepressant or smoking cessation. In one aspect, the invention provides a pharmaceutical formulation comprising a core, including bupropion and its salt derivatives and a coating. The coating may include one or more surfactants and aqueous dispersions of one or more insoluble pharmaceutical acceptable polymers. The core may also include aqueous dispersions of one or more insoluble pharmaceutical acceptable polymers. In another aspect, the invention provides methods for preparing and administering a pharmaceutical composition in oral dosage form, such as a tablet.所揭示者大致係關於藥學藥物組合物、製備口服組合物(例如,長效釋放劑型組合物)的方法、以及治療抗憂鬱或戒煙的方法。一方面,本發明提供一種藥學配方,包含一藥核(其內含有丁氨苯丙酮及其鹽類衍生物)及一塗層。該塗層可包括一或多界面活性劑和一或多不溶性藥學可接受聚合物的水性分散物。該藥核也可包括一或多不溶性藥學可接受聚合物的水性分散物。在另一方面,本發明提供用以製備及施用該以口服劑型(例如,藥錠)存在之藥學組合物的方法。
