CHOI, YOUN WOONG,최연웅,CHO, SANG MIN,조상민,MIN, BYUNG GU,민병구,KIM, BO KYUNG,김보경,JANG, JAE SANG,장재상,KANG, HYUN JU,강현주
申请号：
KR1020120039907
公开号：
KR1020130117128A
申请日:
2012.04.17
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A sustained release tablet containing levodropropizine is provided to show immediate antitussive and apophlegmatic effects through oral administration, to maintain a drug in plasma in a constant concentration, and to reduce administration frequency. CONSTITUTION: A sustained release tablet containing levodropropizine comprises: an immediate release layer containing levodropropizine； and a sustained release layer containing levodropropizine and release-controlling polymers. The content of levodropropizine in the immediate release layer and the sustained release layer is 10-70 mg and 20-80 mg, respectively. A method for manufacturing the sustained release tablet comprises the steps of: mixing levodropropizine, the release-controlling polymers, and additives and preparing the sustained release granules by a wetting or drying method； adding a lubricant to a mixture of the sustained release granules and levodropropizine and tableting the final mixture. [Reference numerals] (AA) Control medicine-test medicine comparison elution (%)； (BB) Elution rate (%)； (CC) Control medicine； (DD) Time (min)본 발명은 레보드로프로피진을 포함하는 속방층과, 레보드로프로피진 및 방출제어용 고분자를 포함하는 서방층으로 이루어지는 레보드로프로피진 서방정에 관한 것이다.
