Antione De Saizieu,Ann Fowler,Regina Goralczyk,Claus Kilpert,Goede Schueler,Christof Wehrli
申请号：
US14016265
公开号：
US08748491B2
申请日:
2013.09.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl； R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl； R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy； R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl； R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy； R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—； or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—； R6 is hydrogen, or R5 and R6 together to form a bond； R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl； R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
