AKIREDDY, SRINIVASA RAO,BHATTI, BALWINDER SINGH,JOSEPH, RONALD,MELVIN, MATT S.,SPEAKE, JASON,XIAO, YUNDE,YOHANNES, DANIEL
申请号：
PE0022102012
公开号：
PE07752013A1
申请日:
2011.05.24
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to non competitive antagonists of nicotinic receptors compounds of formula (i) wherein: R1 and R2 individually is H, alkyl of C1 - C6 C1 - C6 substituted alkyl, aryl, among others R3 is H, alkyl of C1 - C6, R7 is individually H or c1-c6 alkyl, alkoxy C1 - C6, L1 is A Ector selected from the group consisting of cr8r9, cr8r9cr10r11 or R8, R9, R10, R11 is H, alkyl of C1 - C6L2 is a Connector selected from the group consisting of CH2, ch2ch2, ch2ch2ch2 and ch2ch2ch2ch2. Preferred compounds are: hydrochloride [3 - (n, dimetilespir Bicyclo [2.2.1] heptane - 2,1\u00b4 - ciclopropan] - 3 - amine hydrochloride n, Oct - dimethylspiro [3] Bicyclo [5] eno 2,1\u00b4 - ciclopentan] amine hydrochloride and - 3, 3 - dimethylspiro [Bicyclo [2.2.2] octane 2,1\u00b4 - ciclopentan] - 3 - amina, among others.These compounds are useful in the Treatment or prevention of a disease mediated by neuronal nicotinic receptor.SE REFIERE A COMPUESTOS ANTAGONISTAS NO COMPETITIVOS DE RECEPTORES NICOTINICOS DE FORMULA (I) DONDE: R1 Y R2 INDIVIDUALMENTE ES H, ALQUILO DE C1-C6, ALQUILO C1-C6 SUSTITUIDO CON ARILO, ENTRE OTROS R3 ES H, ALQUILO DE C1-C6, R7 ES INDIVIDUALMENTE H, ALQUILO DE C1-C6, O ALCOXI DE C1-C6 L1 ES UN CONECTOR SELECCIONADO DEL GRUPO FORMADO POR CR8R9, CR8R9CR10R11, O R8,R9,R10,R11 ES H, ALQUILO C1-C6 , L2 ES UN CONECTOR SELECCIONADO DEL GRUPO FORMADO POR CH2, CH2CH2, CH2CH2CH2 Y CH2CH2CH2CH2. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE N,3-DIMETILESPIR[BICICLO[2.2.1]HEPTANO-2,1´-CICLOPROPAN]-3-AMINA CLORHIDRATO DE N, 3-DIMETILESPIRO[BICICLO]OCT[5]ENO-2,1´-CICLOPENTAN]-3-AMINA Y CLORHIDRATO DE N,3-DIMETILESPIRO[BICICLO[2.2.2]OCTANO-2,1´-CICLOPENTAN]-3-AMINA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN ELTRATAMIENTO O PREVENCION DE UNA ENFERMEDAD MEDIADA POR UN RECEPTOR NICOTINICO NEURONAL.
