8- [6- [3- (Amino) propoxy] -3-pyridyl] -1-isopropyl-imidazo [4,5 as a selective modulator of vasodilator ataxia mutation (ATM) kinase for the treatment of cancer -C] quinolin-2-one derivatives

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专利权人:

アストラゼネカ・アクチエボラーグ

发明人:

カート・ゴードン・パイク,ベルナール・クリストフ・バルラーム,トーマス・アンソニー・ハント,アンドリュー・ジョン・イーサートン

申请号：

JP2018513812

公开号：

JP6605130B2

申请日:

2016.09.15

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

and pharmaceutically acceptable salts thereof, where R1, R2, R3, R4 and R5 have any of the meanings defined herein. The specification also relates to the use of compounds of Formula (I) and salts thereof to treat or prevent ATM mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising substituted imidazo[4,5-c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof； kits comprising such compounds and salts； methods of manufacture of such compounds and salts； and intermediates useful in such manufacture.

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