SARI ALON;Raul CHERTKOFF;PROTALIX LTD.;YOSEPH SHAALTIEL;EINAT ALMON
发明人:
SARI ALON,YOSEPH SHAALTIEL,EINAT ALMON,Raul CHERTKOFF
申请号：
IL26786319
公开号：
IL267863D0
申请日:
2019.07.04
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
Methods of treating Fabry disease via administration of stabilized plant recombinant human alpha galactosidase protein comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety, and unit dosages of protein are disclosed herein. The disclosed protocols are safe, have greater than 2 week intervals between administrations and exhibit important improvement in patient's disease parameters, in terms of reduced Gb3 accumulation, pain and GI parameters, kidney and cardiac stabilization in the clinical setting.
