Avidor Shulman,Ilya Ruderfer,Tehila Ben Moshe,Talia Shekhter,Yaniv Azulay,Yoseph Shaaltiel,Tali Kizhner
申请号：
US14936720
公开号：
US09708595B2
申请日:
2015.11.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
