PRECAUTIONARY, PREVENTIVE, OR THERAPEUTIC SUBSTANCE FOR CORNEAL DISEASE OR CORNEAL DAMAGE, CELL SHEET, CELL CULTURE SUPPLEMENT, AND METHOD OF CULTURING CELLS
A precautionary, preventive, or therapeutic substance for corneal disease or corneal damage of the present invention is characterized by including a polypeptide as an active ingredient, which includes a region consisting of any one of a polypeptide selected from the group consisting of the following (a) to (c): (a) a polypeptide composed of at least 70 consecutive amino acids in an amino acid sequence represented by sequence identification number 4 and including a region of 166aa to 235aa in the sequence identification number 4, (b) a polypeptide composed of at least 70 consecutive amino acids in an amino acid sequence represented by sequence identification number 2 and including a region of 166aa to 235aa in the sequence identification number 2, and (c) a polypeptide having at least 80 percent of sequence homology with the polypeptide (a) or (b).本發明之角膜疾病或角膜損傷的預防、抑制或治療劑之特徵在於是以含有多肽做為有效成分,且該多肽含有由選自以下(a)~(c)所構成群組中之任一多肽構成的區域。(a)由序列編號4所示胺基酸序列中之連續70個以上的胺基酸構成,且含有序列編號4中166aa~235aa區域的多肽、(b)由序列編號2所示胺基酸序列中之連續70個以上的胺基酸構成,且含有序列編號2中166aa~235aa區域之多肽、(c)具有與(a)或(b)之多肽80%以上序列相同性的多肽。
