KITA JUNICHIRO,北 淳一郎,FUJIWARA HIROSHI,藤原 寛,TAKAMURA SHINJI,高村 真司
申请号：
JP2016170684
公开号：
JP2017014270A
申请日:
2016.09.01
申请国别(地区):
JP
年份:
2017
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a compound and a pharmaceutical composition having antihistaminic activity and antiallergic activity, less in hygroscopic property and excellent in physical and chemical stability.SOLUTION: There is provided benzene sulfonate of (S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butanoic acid represented by the formula (I) and a pharmaceutical composition containing of the compound. There is provided an acid addition salt of an optical active piperidine derivative by salt formation reacting the optical active piperidine derivative as (S) body with absolute configuration of the compound and a benzene sulfonic acid.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】吸湿性が少なく、物理化学的安定性に優れている抗ヒスタミン活性及び抗アレルギー活性を有する化合物および医薬組成物の提供。【解決手段】式(I)で示される(S)-4-〔4-〔(4-クロロフェニル)(2-ピリジル)メトキシ〕ピペリジノ〕ブタン酸のベンゼンスルホン酸塩、および該化合物を含有する医薬組成物。前記化合物の絶対配置が(S)体である光学活性ピペリジン誘導体とベンゼンスルホン酸とを塩形成反応させる、光学活性ピペリジン誘導体の酸付加塩。【選択図】なし
