The invention relates to a method for making a device (1) for the skin application of a substance, that comprises using an electrohydrodynamic spraying (or electrospray) method for depositing the substance onto the device. The method particularly includes the steps of placing a substrate (31) at a distance from a spraying nozzle (11), feeding a liquid formulation (21) containing the substance towards the spraying nozzle (11), and submitting the formulation (21) to an electric field in order to form an aerosol (22) between the nozzle (11) and the substrate (31), and collecting on the substrate (31) the particles formed from said aerosol (22).
