IYER, Raman Mahadevan,LAINE, Dramane Ibrahim,LOPEZ-TAPIA, Francisco Javier,PHILLIPS, Jonathan E.,STEVENSON, Christopher
申请号：
EPEP2013/074803
公开号：
WO2014/083026A1
申请日:
2013.11.27
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3- hydroxymethyl-4-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-6-ylamino)- 6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1- ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2- hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2- ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.L'invention concerne les composés inhibiteurs de Btk 6-tert-Butyl-8-fluoro-2-{3- hydroxyméthyl-4-[1-méthyl-5-(1'-méthyl-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-6-ylamino)- 6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1- ylméthyl-1-méthyl-1H-pyrazol-3-ylamino)-1-méthyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2- hydroxyméthyl-phényl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-méthyl-propionitrile, et 6-tert-Butyl-2-[2-hydroxyméthyl-3-(5-{5-[(2-méthoxy-éthylamino)-méthyl]-pyridin-2- ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, des formulations de ces composés et des procédés de traitement de l'asthme.
