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P38 MAP KINASE INHIBITORS
专利权人:
RESPIVERT LIMITED
发明人:
ITO, KAZUHIRO,STRONG, PETER,RAPEPORT, WILLIAM, GARTH,MURRAY, PETER, JOHN,KING-UNDERWOOD, JOHN,WILLIAMS, JONATHAN, GARETH,ONIONS, STUART, THOMAS,HIRST, SIMON CHRISTOPHER,TADDEI, DAVID, MICHEL, ADRIEN,C
申请号:
NZ59310409
公开号:
NZ593104A
申请日:
2009.12.11
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed herein are pyrazol-pyridine compounds of formula (IA), wherein the substituents are as defined within the specification; processes for its preparation, compositions comprising said compounds and uses thereof. Said compounds ar useful as inhibitors of p38 mitogen-activated protein kinase enzymes (p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof and as such is useful in the treatment of COPD, chronic bronchitis, emphysema, asthma, paediatric asthma, cystic fibrosis, sarcoidosis, idiopathic pulmonary fibrosis, allergic rhinitis, rhinitis, sinusitis, allergic conjunctivitis, conjunctivitis, allergic dermatitis, contact dermatitis, psoriasis, ulcerative colitis, inflamed joints secondary to rheumatoid arthritis or osteoarthritis, rheumatoid arthritis, pancreatitis, cachexia, inhibition of the growth and metastasis of tumours including non-small cell lung carcinoma, breast carcinoma, gastric carcinoma, colorectal carcinomas and malignant melanoma. Specifically preferred examples include: · N-(4-(2-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)ethoxy)pyridin-2-yl)-2-methoxyacetamide; · N-(4-(1-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)ethyl)pyridin-2-yl)-2-methoxyacetamide; · N-(4-(2-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)-2-methylpropyl)pyridin-2-yl)-2-methoxyacetamide; · N-(4-(2-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)propyl)pyridin-2-yl)-2-methoxyacetamide; · N-(4-(1-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)propan-2-yl)pyridin-2-yl)-2-methoxyacetamide; · N-(4-(1-(4-(3-(3-tert-butyl-1-p-tolyl-1-pyrazol-5-yl)ureido)naphthalen-1-yloxy)-2-methylpropan-2-yl)pyridin-2-yl)-2-methoxyacetamide;
来源网站:
中国工程科技知识中心
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