The present invention relates to a N -phenyl- N' -phenoxycarbonyl-phenylsulfonhydrazide derivative with excellent inhibitory activity on PGE 2 production, a method for preparing the same and a pharmaceutical composition comprising the same as an active ingredient. The present N -phenyl- N' -phenoxycarbonyl-phenylsulfonhydrazide derivative may be used effectively for preventing or treating inflammation, arthritis, high fever, pain, cancer, stroke or bone disease.