Jaspart, Severine Francine Isabelle,PLATTEEUW, Johannes Jan,van den Heuvel, Denny Johan Marijn
申请号：
HUE16175091
公开号：
HUE037383T2
申请日:
2016.06.17
申请国别(地区):
HU
年份:
2018
代理人:
摘要：
The invention provides an orodispersible solid pharmaceutical dosage unit having a weight between 30 and 1,000 mg, said dosage unit consisting of: €¢ 0.1-25 wt.% of estetrol particles containing at least 80 wt.% of an estetrol component selected from estetrol, estetrol esters and combinations thereof； and €¢ 75-99.9 wt.% of one or more pharmaceutically acceptable ingredients； the solid dosage unit comprising at least 100 µg of the estetrol component； and wherein the solid dosage unit can be obtained by a process that comprises compressing a dry blend of estetrol particles and one or more pharmaceutically acceptable excipients into a solid dosage unit. The solid dosage unit is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration.
