PROBLEM TO BE SOLVED: To provide a modified VII factor polypeptide and a use method thereof.SOLUTION: This invention provides a modified FVII polypeptide wherein the modified FVII polypeptide shows increased tissue factor (TF)-dependent coagulation activity compared to an unmodified FVII polypeptide, and an active fragment thereof. This invention provides a nucleic acid molecule containing a nucleotide sequence encoding the modified FVII polypeptide. This invention provides a vector containing the nucleic acid molecule. This invention provides a cell containing the vector. This invention provides a method of producing a modified FVII polypeptide which includes a step of culturing the cell. This invention provides a pharmaceutical composition containing, in a pharmaceutically acceptable carrier, a therapeutically effective concentration or amount of the modified FVII polypeptide, or the nucleic acid molecule or the vector or the cell.【課題】改変第ＶＩＩ因子ポリペプチド及びその使用方法を提供する。【解決手段】変ＦＶＩＩポリペプチドが、非改変ＦＶＩＩポリペプチドと比較して、増大した組織因子（ＴＦ）依存性凝固活性を示す、改変ＦＶＩＩポリペプチド、又はその活性断片。前記改変ＦＶＩＩポリペプチドをコードするヌクレオチドの配列を含む核酸分子。前記核酸分子を含むベクター。前記ベクターを含む細胞。前記細胞を培養する工程を含む、改変ＦＶＩＩポリペプチドの製造方法。薬学的に許容される媒体中に、治療に有効な濃度又は量の前記改変ＦＶＩＩポリペプチド、又は前記核酸分子又は前記ベクター又は前記細胞を含む医薬組成物。【選択図】なし
