BAMBA Makoto,FURUYAMA Hidetomo,NIIYAMA Kenji,SAKAMOTO Toshihiro,SUNAMI Satoshi,TAKAHASHI Keiji,YAMAMOTO Fuyuki,YOSHIZUMI Takashi,YAMAMOTO F
申请号:
SI200831719
公开号:
SI2168966T1
申请日:
2008.06.12
申请国别(地区):
SI
年份:
2017
代理人:
摘要:
The invention relates to a compound of a general formula (I): wherein A 1 and A 2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R 1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R 2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.