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DERIVAT BICIKLOANILINA
专利权人:
MSD K.K.
发明人:
Bamba, Makoto,Furuyama, Hidetomo,Niiyama, Kenji,Sakamoto, Toshihiro,Sunami, Satoshi,Takahashi, Keiji,Yamamoto, Fuyuki,Yoshizumi, Takashi
申请号:
HRP20161536
公开号:
HRP20161536T1
申请日:
2016.11.21
申请国别(地区):
HR
年份:
2016
代理人:
摘要:
The invention relates to a compound of a general formula (I): wherein A 1 and A 2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R 1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R 2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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