ANTIVIRAUX À LARGE SPECTRE CONTRE DES PROTÉASES 3C OU 3C-ASSOCIÉES DU SUPER-GROUPE DES PICORNAVIRUS-ASSOCIÉS : PICORNAVIRUS, CALICIVIRUS ET CORONAVIRUS
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION;WICHITA STATE UNIVERSITY;THE OHIO STATE UNIVERSITY
发明人:
CHANG, KYEONG-OK,KIM, YUNJEONG,GROUTAS, WILLIAM C.,HUA, DUY,SAIF, LINDA J.
申请号：
EP12837222
公开号：
EP2760827A4
申请日:
2012.09.27
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.
