Disclosed herein is the use of terfenadine in the manufacture of a medicament for inhibiting the growth or metastasis of a human breast or human ovarian tumor, for treating a disease or disorder associated with angiogenesis in a human in need thereof, wherein the disease or disorder is selected from the group consisting of restenosis, rheumatoid arthritis, Crohn&rsquos disease, diabetic retinopathy, psoriasis, endometriosis, macular degeneration, neovascular glaucoma, and adiposity.