A kind of Microsphere manufacture device of easy adjustment particle size, comprising: substrate, the first fluid channel, sleeve, screw, the second fluid channel, the first mixing fluid channel and third fluid channel. Channel is equipped in substrate,And communicated with the outside world with screw hole,A conical surface is formed between channel and screw hole； First fluid channel is space in the pipe of a long tubule,Long tubule head end forms the first inlet,Tail end has tubule outlet end； Sleeve covers between the long tubule of what and channel； Screw has central through hole,And it is inserted in long tubule Hou spiral shell and consolidates what screw hole； Second fluid channel has the second inlet,And it is in communication by two side of the left and right of the first fluid channel； First mixing fluid channel connection what tubule outlet end and 2 second fluid channel meets,And there is an outlet end； Third fluid channel is connected to third fluid channel,And there is third inlet.一種易調整粒徑大小的微球製造裝置，包括：基板、第一微流道、套筒、螺絲、第二微流道、第一混合微流道及第三微流道。基板內設有通道，並以螺孔與外界相通，通道與螺孔之間形成一錐面；第一微流道為一長細管之管內空間，長細管頭端形成第一注入口，尾端具有細管出口端；套筒套於長細管與通道之間；螺絲具有中心通孔，並套入長細管後螺固於螺孔；第二微流道具有第二注入口，且由第一微流道的左右二側與之連通；第一混合微流道連接於細管出口端與二第二微流道匯合處，並具有一出口端；第三微流道連通第三微流道，且具有第三注入口。
