PROBLEM TO BE SOLVED: To provide a system for manufacturing sustained release pharmaceutical products from which undesired small particles are removed during manufacture of drug-containing microspheres.SOLUTION: A system comprises: a vessel containing a suspension of solidified microspheres in suspending medium； a hydrocyclone (HC-1) 10 having a fluid inlet 16, a first fluid outlet 18, and a second fluid outlet 20, where the fluid inlet 16 is in fluid communication with the vessel and receives the suspension, the second fluid outlet 20 exhausts a flow of suspension containing more concentrated microspheres than the suspension in the vessel, and the first fluid outlet 18 exhausts a flow of suspension containing less concentrated microspheres than the suspension in the vessel； a solvent removal vessel (SRV) comprising an inlet in fluid communication with the second fluid outlet 20； and a wet sieve or a hollow fiber filter comprising an inlet in fluid communication with the outlet of the SRV and an outlet in fluid communication with the inlet of the SRV.SELECTED DRAWING: Figure 1【課題】薬物含有微小球の製造において、望ましくない小粒子の除去した、徐放性医薬製品を製造するシステムの供給。【解決手段】懸濁媒体に凝固した微小球の懸濁液が入っている容器と流体入口１６、第１の流体出口１８、及び第２の流体出口２０を具備する液体サイクロン（ＨＣ－１）１０であって、流体入口１６が容器に流体連絡して懸濁液を受容し、第２の流体出口２０が、容器中の懸濁液に比べて高い濃度の微小球を含む懸濁液の流れを排出し、第１の流体出口１８が、容器中の懸濁液に比べて低い濃度の微小球を含む懸濁媒体の流れを排出する、液体サイクロン１０と、第２の流体出口２０と流体連結している入口を具備する溶媒除去容器（ＳＲＶ）と、ＳＲＶの出口と流体連結している入口とＳＲＶの入口と流体連結している出口を具備する湿潤篩または中空糸フィルタと、を備える、システム。【選択図】図１
