This Hair Ming Department disclose the compound of Ju You structure Formulas IIOr Which, wherein R As are subjected on its Drug LearnOrR1, R2, R3, R4 and R5 As H, alkyl or alkoxyalkylR6 As Hydrogen, alkyl, Hydroxyalkyl alkyl or-CH2FR7, R8 and R9 As H, alkyl, alkoxy, alkylthio group, alkoxyalkyl, Halogen elements or-CF3And Z As can Visual need the aryl, Miscellaneous Fang Ji Huo Miscellaneous aryl-alkyls of The substitutions. Also compound of formula I is disclosed, other control Treatment Parkinsons diseases System Elixirs And use to Single Independence Huo With, and Pivot minds The Xi System disease , Te Do are the purposes in Parkinsons disease in controlling Treatment, and close object including Qi Medical Drug Group.本發明係揭示具有結構式I之化合物I或其在藥學上可接受之鹽,其中R為或R1、R2、R3、R4和R5為H、烷基或烷氧烷基;R6為氫、烷基、羥烷基或-CH2F;R7、R8和R9為H、烷基、烷氧基、烷硫基、烷氧烷基、鹵素或-CF3;且Z為可視需要經取代之芳基、雜芳基或雜芳基-烷基。亦揭示式I化合物,單獨或與其他治療帕金森氏症之製劑併用,在治療中樞神經系統疾病,特別是帕金森氏症上的用途,以及包括其之醫藥組合物。
