NEUSTADT, BERNARD,BOYLE, CRAIG,CHACKALAMANNIL, SAMUEL,HARRIS, JOEL,LANKIN, CLAIRE,LIU, HONG,SHAH, UNMESH,STAMFORD, ANDREW
申请号：
AT06803715
公开号：
AT538123T
申请日:
2006.09.15
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R1-isoxazolyl, R1-oxadiazolyl, R1-dihydrofuranyl, R1-pyrazolyl, R1-imidazolyl, R1-pyrazinyl or R1-pyrimidinyl； R1 is 1, 2 or 3 substituents selected from H, alkyl, alkoxy and halo； Z is optionally substituted-aryl, or optionally substituted-heteroaryl； are disclosed, as well as their use in the treatment of central nervous system diseases, in particular Parkinson's disease and Extra Pyramidal Syndrome, pharmaceutical compositions comprising them, and combinations with other agents.
