The present application relates to compounds of formula Iwherein R<；sup>；1<；/sup>；, R<；sup>；2<；/sup>；and R<；sup>；3<；/sup>；are as defined herein and such compounds are for use in a method of treating, preventing or managing cancer. Said cancer can be leukemia. Said method can further comprise administering a second agent. Pharmaceutical compositions and single unit dosage forms comprising such compounds are also provided.
