DAVID WILLIAM TONGE;SUSAN ANN CARTLIDGE;GADI GAZIT-BORNSTEIN;ASTRAZENECA AB;OLIVIA RAEBER;XIADONG YANG
发明人:
DAVID WILLIAM TONGE,OLIVIA RAEBER,GADI GAZIT-BORNSTEIN,XIADONG YANG,SUSAN ANN CARTLIDGE
申请号：
IL19171808
公开号：
IL191718A
申请日:
2008.05.26
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3.
