RAEBER, OLIVIA,GAZIT-BORNSTEIN, GADI,YANG, XIAODONG,CARTLIDGE, SUSAN ANN,TONGE, DAVID WILLIAM
申请号：
CA2633956
公开号：
CA2633956C
申请日:
2006.12.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Binding proteins, such as antibodies directed to IGF-II with cross-reactivityto IGF-I and uses of such antibodiesare described. In particular, fully human monoclonal antibodies directed tothe IGF-II with cross-reactivity to IGF-I are disclosed.Also discussed are nucleotide sequences encoding, and amino acid sequencescomprising, heavy and light chain immunoglobulinmolecules, particularly sequences corresponding to contiguous heavy and lightchain sequences spanning the framework regionsand/or complementarity determining regions (CDR's), specifically from FR1through FR4 or CDR1 through CDR3.
