A medicine bottle with a solid silica flaky drying agent is disclosed. The solid silica flaky drying agent is wrapped in a filter paper and packed inside a bubble cap on which a number of holes are provided for moisture absorption. The bubble cap containing the solid silica flake drying agent can be attached to the cap of the medicine bottle via 5 a baseplate behind a circular locking notch for preventing the solid silica flake drying agent from falling off the cap, or placed at the bottom of the medicine bottle which has a circular locking notch to prevent the solid silica flake drying agent from falling out of the medicine bottle.
