Michael Zamloot,Cherng-chyi Fu,De-Hwa Chao,Andrei Blasko,Su Il Yum
申请号：
US12329318
公开号：
US09339463B2
申请日:
2008.12.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10μ or less than or equal to 20μ are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.
