Biohaven Pharmaceutical Holding Company Limited (B
发明人:
Allen B. Reitz,Garry Robert Smith
申请号：
US16518008
公开号：
US20200000818A1
申请日:
2019.07.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Pharmaceutical compositions of the invention include substituted riluzole pro drugs useful for the treatment of amyotrophic lateral sclerosis (ALS) and related disorders through the release of riluzole, especially to avoid patient to patient variability in first pass, hepatic metabolism promoted by Cyp 1A2. Pro-drugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. The invention further includes pro-drugs of riluzole useful for the treatment of disease states that can be treated with riluzole through the release of riluzole from a pro-drug agent.
