Provided are a taxoid compound as shown in formula (I) and a preparation method and use thereof, wherein the preparation method comprises the following steps of: firstly protecting the two hydroxyl groups of gemcitabine, then condensing same with alkyl chloroformate, and then removing the hydroxyl protecting group to obtain the intermediate G1； respectively protecting the hydroxyl group of G1, and then removing the first hydroxyl protecting group to obtain the intermediate G2； reacting 7,10-di(trichloroethoxy carbonyl)docetaxel and dicarboxylic anhydride to obtain the intermediate D1； condensing D1 and G2 to obtain the intermediate D2； and deprotecting the carboxyl group of D2 to obtain the target product. The compound of formula I can be used to inhibit solid tumors such as gastrointestinal cancer, lung cancer, breast cancer and leukemia.
