DIX DANIEL B,GRAHAM KENNETH S,KAMEN DOUGLAS E,WALSH SCOTT M
申请号：
NZ60111411
公开号：
NZ601114A
申请日:
2011.01.07
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
NZ 601114 Disclosed is a stable pharmaceutical formulation comprising: a human antibody that specifically binds to human interleukin-6 receptor (hIL-6R), wherein the antibody comprises a heavy chain variable region having the amino acid sequence of SEQ ID NO:18 and a light chain variable region having the amino acid sequence of SEQ ID NO:26, wherein the sequences are as defined in the complete specification histidine at a concentration of from 25 mM to 100 mM arginine at a concentration of from 25 mM to 50 mM sucrose in an amount of from 3% to 10% w/v and polysorbate in an amount of from 0.1 % to 0.2% w/v.
