МУДЖИКА Александр О. (US),БУРОВА Елена (US),МЕРФИ Эндрю Дж. (US)
申请号：
RU2018117944
公开号：
RU2018117944A
申请日:
2016.11.18
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Lymphocyte activation gene 3 (Lag3). Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Lag3 locus so that said non-human animals express a Lag3 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
