Systems and methods for translating medical imaging data for processing using a general processing graphic processing unit (GPGPU) architecture are provided. Medical imaging data acquired from a patient and having data characteristics incompatible with processing on the GPGPU architecture, including at least one of bit-resolution, memory capacity requirements for processing, or bandwidth requirements for processing is translated for processing by the GPGPU architecture. The translation process is performed by determining a plurality of window level settings using a machine learning network to increase conspicuity of an object in an image generated from the medical imaging data or generate at least two channel image datasets from the medical imaging data. Translated medical image data is crated using at least one of the window level settings or at least two channel image datasets and then processed using the GPGPU architecture to generate medical images of the patient.
