KIM Chihwa,LEE Jaehyeon,JO Eui-Cheol,KIM Jung-Seob
申请号：
US201715848149
公开号：
US2018168134(A1)
申请日:
2017.12.20
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
A transgenic mouse expressing inactivated human iduronate-2-sulphatase (IDS) and a method for improving agents for treating Hunter syndrome using the transgenic mouse are provided. The transgenic mouse expressing the inactivated human IDS, which has immune tolerance to IDS, does not cause an immune response to IDS which is an active component of the agents for treating Hunter syndrome, and thus the transgenic mouse may be effectively used to identify immunogenic factors other than the immunogenicity of the protein components of the agents.
