Prodrug of an ICE inhibitor

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

WANNAMAKER, MARION W.,DAVIES, ROBERT J.

申请号：

DK10177537

公开号：

DK2270005T3

申请日:

2001.05.18

申请国别(地区):

DK

年份:

2015

代理人:

摘要：

This invention described an ICE inhibitor prodrug (I) having good bioavailability. Compound of formula (I) is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma. <；CHEM>；

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