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Substituted N-arylethyl-2-arylquinoline-4-carboxamides and their use
专利权人:
BAYER AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
BECK, Hartmut,KAST, Raimund,MEININGHAUS, Mark,FURSTNER, Chantal,DIETZ, Lisa,STELLFELD, Timo,ANLAUF, Sonja,VON BUHLER, Clemens-Jeremias,BAIRLEIN, Michaela,ANLAHR, Johanna,MUNSTER, Uwe,TERJUNG, Carsten
申请号:
PE2019002010
公开号:
PE20191616A1
申请日:
2018.04.04
申请国别(地区):
PE
年份:
2019
代理人:
摘要:
1. The invention is directed to the substitute compound of n-ariletil-2-arilquinolin-4-carboxamida formula (I) and its acceptable salts, oxidants and solutions, wherein: AR is phenyl or substituted pyridine, substituted by fluorination, chlorine, etc.; it is a link or a formula group; 1-x - (cr10ar10b) k -, K -, 35; 2 O ± 35; 1-pirrolidin -; 352 X is the link, CH2-IsAmong others, r10a and r10b are hydrogen, fluorine or methyl, or form a cyclopropene group together with carbon atom; K is 0-4; R1 is halogen until pentachlorobenzene is replaced by fluorinated (C1-C4) tar; R2, R3 and R4 are independent hydrogen, halogen or methyl to carbon trifluoride; R5 refers to bittern, up to pentabromodiphenyl (C1-C4) tar, etc.; R6 refers to the benzene that may have three-star properties, which can be replaced by a substitute with identification characteristics or a substitute different from fluorination, chlorine, methyl, etc;R7a and r7b are independent of another hydrogen or methyl, or form a cyclopentadiene together with the carbon atom attached to them; R8 is hydrogen, fluorine, etc.; R9 is hydrogen or methyl. These compounds are non prostate potent antigens, chemical and metabolic stabilizers of prostaglandin F2 α receptor (PGF2). -FP,It is very useful in the treatment or prevention of meningitis, pulmonary fibrosis, pulmonary hypertension, flammable fiber disorder and fibrosis. He also mentioned composers who had these things in themLa presente invencion se refiere a compuestos derivados sustituidos de N-ariletil-2-arilquinolin-4-carboxamida de Formula (I) y sus sales, N-oxidos y solvatos aceptables del mismo, donde: Ar es fenilo o piridilo opcionalmente sustituidos con fluor, cloro, entre otros; Y es un enlace o un grupo de la formula #1-X-(CR10AR10B)k-#2 o #1-pirrolidin-#2; X es enlace, -CH2-, -O-, entre otros; R10A y R10B independientemente son hidrogeno, fluor o metilo o juntos forman junto con el atomo de carbono al que estan unidos un grupo ciclopropilo; k es 0 a 4; R1
来源网站:
中国工程科技知识中心
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