At least one isolated lactic acid bacteria strains selected from the following group: F-1 (Lactobacillus acidophilus), AP-32 (Lactobacillus salivarius), GL-104 (Lactobacillus reuteri), GL-156 (Lactobacillus paracasei), RE-78 (Lactobacillus helveticus), CT-53 (Lactobacillus rhamnosus) and ET-66 (Lactobacillus paracasei) are provided. The above-mentioned lactic acid bacteria strains have a function of inhibiting of oral pathogens and is used in a form of food, oral cleaning or pharmaceutical compositions.一種選自以下群組中之至少一經分離的乳酸菌菌株:嗜酸乳酸桿菌 (Lactobacilusacidophilus) F-1菌株、唾液乳酸桿菌 (Lactobacillus salivarius) AP-32菌株、羅伊氏乳酸桿菌 (Lactobacillus reuteri) GL-104菌株、副乾酪乳酸桿菌 (Lactobacillus paracasei) GL-156菌株、瑞士乳酸桿菌 (Lactobacillus helveticus) RE-78菌株、鼠李糖乳酸桿菌 (Lactobacillus rhamnosus) CT-53菌株及副乾酪乳酸桿菌 (Lactobacillus paracasei)ET-66菌株。上述乳酸菌菌株具有抑制口腔病原菌之作用,且以食品、口腔清潔或醫藥組合物的形式存在。無