Fertile transgenic animals useful for producing antibodies bearing human variable regions

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专利权人:

Kymab Limited

发明人:

FRIEDRICH, Glenn A.,LEE, E-Chiang

申请号：

AU2016101604

公开号：

AU2016101604B4

申请日:

2016.09.12

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016101604B420161124.pdf#####ABSTRACT The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous antibody chain expression has been inactivated. This inactivation leads to loss of ADAM6 genes located within the rodent heavy chain locus, said genes being crucial for fertility. Introduction of functional copies of said ADAM6 genes allows production of fertile mice. 8153750 1 (GHM.4ter- P9 A880 AI J 1

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