An electro-mechanical drug delivery device (800, 821, 850, 952) comprises a main body (802, 822, 852, 902, 956) having a distal end (808, 828, 910) and a proximal end (806, 826, 958). The distal end (808, 828, 910) is configured to attach to a dispense interface. A separable housing (804, 824, 854, 904, 962) that can prevent an administration of a drug by the drug delivery device (800, 821, 850, 952), the housing configured to cover at least a portion of the distal end (808, 828, 910) of the main body (802, 822, 852, 902, 956) when the separable housing (804, 824, 854, 904, 962) is coupled to the main body (802, 822, 852, 902, 956) of the drug delivery device (800, 821, 850, 952). A conduction element (856, 906) is provided by the main body (802, 822, 852, 902, 956) and configured for establishing an electrical connection with an electrical connector (849, 862, 968). Establishment of the electrical connection is prevented when the housing does not cover at least a portion of the distal end (808, 828, 910) of the main body (802, 822, 852, 902, 956). The electrical connection may be established when the housing covers at least a portion of the distal end (808, 828, 910) of the main body (802, 822, 852, 902, 956) of the drug delivery device (800, 821, 850, 952).Cette invention concerne un dispositif électromécanique dadministration pharmacologique (800, 821, 850, 952) comprenant un corps principal (802, 822, 852, 902, 956) comportant une extrémité distale (808, 828, 910) et une extrémité proximale (806, 826, 958). Lextrémité distale (808, 828, 910) est conçue de manière à être fixée à une interface dadministration. Un boîtier amovible (804, 824, 854, 904, 962) a la capacité dempêcher le dispositif dadministration pharmacologique (800, 821, 850, 952) de délivrer un médicament, le boîtier étant conçu de manière à recouvrir une partie au moins de lextrémité distale (808, 828, 910) du corps principal (802, 822, 852, 902, 956) lorsque le boîtier amovible (804, 824, 854, 904
