SU, WEIKE,LI, JIANJUN,JIANG, ZULIN,XU, JIANKANG,SONG, GANG,CHE, DAQING
申请号：
EP09771966
公开号：
EP2311812A4
申请日:
2009.06.30
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Method for chemical synthesis of oxcarbazepine comprises adding 5-cyano-10-nitro-5H-dibenz[b,f]azepine of formula III, Raney nickel catalyst, and organic solvent into a reactor, adding hydrogen at 2-20A, controlling the temperature to 40-120°C and carrying out reduction reaction, filtering after reacting completely, hydrolyzing the filtrate by adding 20-36.5 mass% hydrochloric acid, concentrating and cooling crystallizing the reaction solution, and obtaining the oxcarbazepion. The method has advantages of advanced process, simple and safe operation, and high product purity and yield, which is suitable for commercial production.
