BENTLEY, MICHAEL D,VIEGAS, TACEY X,GOODIN, RICHARD R,CHENG, LIN,ZHAO, XUAN
申请号：
NZ59483404
公开号：
NZ594834A
申请日:
2004.12.16
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
A method of preparing a monodisperse oligo (ethylene glycol) reagent composition is disclosed, wherein the method comprises the step of reacting a halo-terminated oligo (ethylene glycol) having (m) monomer subunits with a hydroxyl-terminated oligo (ethylene glycol) having (n) monomer subunits under conditions effective to displace said halo group to thereby form an oligo (ethylene glycol) having (m) + (n) monomer subunits (OEGm+m), where (m) and (n) each independently range from 1-10, wherein the reacting step is carried out in the presence of a strong base such as sodium, potassium, sodium hydride, potassium hydride, sodium methoxide, potassium methoxide, sodium tert-butoxide, or potassium tert-butoxide, suitable for converting the hydroxyl group of the hydroxyl-terminated oligo(ethylene glycol) into the corresponding alkoxide.
