Electrosurgical lysing devices and related systems and methods. In some embodiments, the lysing device may comprise a lysing tip comprising a plurality of beads. One or more of the plurality of beads may be electrically non-conductive, at least along their respective surfaces. The lysing tip may further comprise at least one lysing member defining at least one lysing segment extending between each pair of adjacent beads. At least a subset of the plurality of beads may protrude both distally and proximally relative to the at least one lysing member.