GROUPES LYMPHOIDES ASSOCIES A LA GRAISSE COMME SITES DE TRANSPLANTATION, DE REGENERATION TISSULAIRE, D'ORGANOGENESE ET DE FONCTION POUR DE MULTIPLES TISSUS
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
LAGASSE, ERIC
申请号：
CA3052295
公开号：
CA3052295A1
申请日:
2018.02.20
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present disclosure relates to the engraftment and proliferation of cells in fat- associated lymphoid clusters ("FALCs" or "milky spots"), which may be used to generate functional ectopic tissue. The present disclosure further provides methods and compositions for grafting and proliferating cells, in FALCs by activating the lymphotoxin beta receptor (LTßR) and/or NF-?B-inducing kinase (NIK) signaling pathway. The present disclosure also provides for methods and compositions to establish ectopic liver tissue in FALCs (milky spots) and to use such ectopic liver tissue for therapeutic benefit, and provides methods and compositions to generate ectopic kidney tissue in FALCs, which can be used in a subject for therapeutic benefit.
