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METHODS AND COMPOSITIONS FOR THE TREATMENT OF CUSHINGS SYNDROME USING 2S, 4R KETOCONAZOLE
专利权人:
发明人:
Theodore Richard Koziol
申请号:
US16007298
公开号:
US20180338971A1
申请日:
2018.06.13
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Methods for treating Cushings Syndrome and other conditions associated with excessive cortisol production such as Cushings Disease, ectopic adrenocorticotropic hormone secretion, ectopic corticotropin-releasing hormone secretion, adrenal-dependent Cushings Syndrome, adrenal adenoma, adrenal autonomy, or any other condition associated with persistent or recurrent endogenous hypercortisolemia are provided. The methods include administration of a 2S,4R ketoconazole enantiomer substantially free of the 2R,4S enantiomer to patients according to a dosing titration schedule or at an effective amount. Treatment methods according to the invention may be safer and more effective than treatment using racemic ketoconazole.
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