UMAÑA, Pablo,XU, Wei,CLAUS, Christina,FERRARA KOLLER, Claudia,KLEIN, Christian
申请号：
CR20190309
公开号：
CR20190309A
申请日:
2018.01.02
申请国别(地区):
CR
年份:
2019
代理人:
摘要：
The inventor refers to a new biantigen binding molecule, which includes at least one antigen binding domain that specifically binds to 4-1BB. At least some of them can specifically bind to target cell antigens and a FC domain, consisting of a second unit, which can stably bind, produce and use these molecules. Least one antien binding domain capable of specific binding to 4-1BB, at least one moiety capable of specific binding to a target cell antien,And a FC domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.La Invencióm se refiere a nuevas moléculas de unión a antígeno biespecíficas, que comprende al menos un dominio de unión a antígeno capaz de unirse de manera específica a 4-1BB, al menos un resto capaz de unirse de manera específica a un antígeno de célula diana y un dominio Fc formado por una primera y un segunda subunidad capaces de asoaciarse de manera estable y a métodos para producir estas moléculas y a métodos para usar las mismas.The invention relates to new bispecific antigen binding molecules, comprising at least one antigen binding domain capable of specific binding to 4-1BB, at least one moiety capable of specific binding to a target cell antigen, and a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
