A method and system for patient medication therapy self-management. The system performs medication therapy self-management in a fully automated manner, using periodic interactive dialogs with a patient to obtain health state measurements from the patient. The system and method utilizes a computer usable medium having computer readable program code embodied therein for representing a description of a pain in a digitized form allowing the patient to directly interact with the program code via the periodic dialogs. The system and method utilizes a therapy alteration permission level (TAPL) limiting the possible self-adjustments available to the patient to change the patient's therapy. Via the interactive dialogs, the patient self-selects aspect words concerning the patient's current pain allowing the program code to adjust the patient's medication therapy within the TAPL.