A method for skin antiaging treatment comprising administering Botulinum toxinto an area of facial and/or neckskin, combined with the administration of a cosmetic or pharmaceuticalcomposition.comprising a cosmetically or pharmaceuticallyeffective amount of at least one peptide derived from the SNAP-25 proteinand/or at least one enkephalin-derived peptide, and atleast one cosmetically or pharmaceutically acceptable excipient or adjuvant.