Systems and methods for measuring mono-energetic hadron beams are provided. Such systems and methods include a first detection unit having a planar sensor with a sensing area segmented into a matrix of pixels, each pixel being adapted to provide a transit signal indicative of transit of a particle therethrough, and a counting circuit coupled to the sensor for providing an output signal indicative of number of particles Np of the beam crossing said sensing area in a time interval, based on the transit signals provided by said pixels, and a second detection unit arranged downstream of the first detection unit which includes at least one ionization detector for providing an output signal proportional to the total charge Qion released by the beam (B) in the ionization detector in such time interval.